Protein Purification
Selleck Chemical LLC Rigosertib (ON-01910) 50mg 1225497-78-8
Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM in a cell-free assay. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical PKR Inhibitor, Purity: ≥95%, CAS: 608512-97-6, 25 mg
Binds the ATP-binding site of PKR and blocks autophosphorylation (IC50 = 186-210 nM); protects neuroblastoma cells against cell damage triggered by ER stress; prevents phosphorylation of FADD, preventing apoptosis; reduces phosphorylation of PKR and eIF2α in the brain, enhancing long-term memory storage
Cayman Chemical β-Glucuronidase Inhibitor, Purity: ≥98%, CAS: 484006-66-8, 1 mg
An inhibitor of bacterial β-glucuronidase (IC50 = 283 nM for the E. coli enzyme); inhibits wild-type but not Δ360-376 E. coli β-glucuronidase at 100 µM; reduces irinotecan-induced colonic epithelial damage and the number of bloody diarrheal events in a mouse model of chemotherapy-induced intestinal toxicity at 50 mg/kg
Cayman Chemical Cdk2 Inhibitor II, Purity: ≥95%, CAS: 222035-13-4, 5 mg
A 3-(benzylidne)indolin-2-one analog that selectively and potently inhibits Cdk2 (IC50 = 60 nM)
Selleck Chemical LLC Lopinavir 10mg 192725-17-0 ABT-378
Lopinavir (ABT-378) is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical PDE4B Inhibitor, Purity: ≥98%, CAS: 2410550-31-9, 10 mg
A PDE4B inhibitor (IC50 = 140 nM); selective for PDE4B over a panel of 20 PDE isoforms and a panel of 39 CNS receptors at 10 µM; inhibits the activity of PDE4C1, PDE3B, 5-HT2C, and σ2 receptor by >50% activity at 10 µM; decreases LPS- or Pam3Cys-induced TNF-α production in mouse BMDMs at 1 µM; reduces cocaine self-administration and the progressive ratio breakpoint in mice at 5 mg/kg
Cayman Chemical Menin-MLL Inhibitor 20, Purity: ≥98%, CAS: 2448173-47-3, 10 mg
A synthetic intermediate
Cayman Chemical COX Inhibitor Screening Assay Potassium Hydroxide, 1 ea
COX Inhibitor Screening Assay Potassium Hydroxide, 1 ea
Sigma Aldrich Fine Chemicals Biosciences Streptavidin Mag Sepharose
Streptavidin Mag Sepharose(R) is a magnetic bead for simple and efficient enrichment of target proteins by immunoprecipitation and purification of biotinylated biomolecules. Streptavidin Mag Sepharose(R) utilizes the strong interaction between biotin and streptavidin ligand which is immobilized on magnetic beads. Magnetic beads simplify sample handling in small-scale purifications.
Sigma Aldrich Fine Chemicals Biosciences Streptavidin Mag Sepharose
Streptavidin Mag Sepharose(R) is a magnetic bead for simple and efficient enrichment of target proteins by immunoprecipitation and purification of biotinylated biomolecules. Streptavidin Mag Sepharose(R) utilizes the strong interaction between biotin and streptavidin ligand which is immobilized on magnetic beads. Magnetic beads simplify sample handling in small-scale purifications.
Cayman Chemical Menin-MLL Inhibitor 20, Purity: ≥98%, CAS: 2448173-47-3, 50 mg
A synthetic intermediate
Cayman Chemical Prostaglandin D2 Inhibitor, Purity: ≥98%, CAS: 885066-67-1, 10 mg
A PGD2 receptor antagonist (DP; IC50 = 0.3 nM); inhibits PGD2-induced cAMP accumulation in LS 174T cells that endogenously express the DP receptor
Cayman Chemical HIV-1 Integrase Inhibitor 1, Purity: ≥98%, CAS: 729607-74-3, 25 mg
An inhibitor of HIV-1 integrase DNA strand transfer (IC50 = 14 nM); an inhibitor of SARS-CoV-2 Mpro at 10 µM in a fluorescence-based assay; decreases SARS-CoV-2 replication (EC50 = 0.27 µM) and reduces PFUs in infected Huh7.5 cells in a concentration-dependent manner